Pri PEPTIDES SWITCH ON TRANSCRIPTION FACTOR

Transcription factor abundance controlled by an auto-regulatory mechanism involving a transcription start site switch

A transcriptional feedback loop is the simplest and most direct means for a transcription factor to provide an increased stability of gene expression. In this work performed in human cells, we reveal a new negative auto-regulatory mechanism involving an alternative transcription start site (TSS) usage. Using the activating transcription factor ZNF143 as a model, we show that the ZNF143 low-affi...

Supramolecular hydrogels based on short peptides linked with conformational switch.

Short peptides appropriately linked with an azobenzene conformational switch were found to be motif and pH dependant supramolecular hydrogelators. The hydrogelation properties of the short peptides linked with the conformational switch were studied in detail with respect to dependence on amino acid residue, pH and salt effect. The presence of amino acids with aromatic side chains such as Phe an...

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription

The isotype specificity of immunoglobulin (Ig) class switching is regulated by a cytokine which induces transcription of a specific switch (S) region, giving rise to so-called germline transcripts. Although previous studies have demonstrated that germline transcription of an S region is required for class switch recombination (CSR) of that particular S region, it has not been shown whether the ...

metabolic syndrome and mitochondrial transcription factor a

A transcription switch toggled by noncoding RNAs.

L ife is really getting complicated in the world of eukaryotic transcription. In the good old days, we were comfortable in the belief that transcription occurred primarily across the coding region of a gene, producing an mRNA for translation. However, over the past few years, this view has been turned topsy-turvy. Improved microarray and sequencing technologies have revealed that our picture of...